An upregulation of RhoA/Rho-kinase associated with the augmented smooth muscle contractility has also been reported in rat myomertium during pregnancy [42,43], arterial smooth muscle of spontaneously hypertensive rats [12], coronary vasospasm in pigs [16], dog femoral artery in heart failure [44], and BSMs in rat experimental asthma [21]. The gene discussed is RHOA; the disease is heart failure.