In contrast to the mouse model of osteogenic sarcoma [19], where reactivation of c-Myc in growth-arrested, re-differentiated osteocytes induced their rapid demise through apoptosis, reactivation of c-Myc in islet tumours did not lead to an increase in the number of cells undergoing apoptosis compared to the original islet tumours formed after 14 days of c-Myc activation (Figure 2). The gene discussed is MYC; the disease is osteosarcoma.