Importantly, in contrast to partially regressed islet tumours (9 days of c-Myc inactivation), where most apoptotic cells were found in the vasculature (Figure 2), the majority of apoptotic cells in both the original 14-day islet tumours and reactivated tumours were not present within the vasculature but rather found predominantly adjacent to blood vessels (averages of 3–4 cells per islet section c-Myc 'on' versus 3–5 cells per islet c-Myc 'on-off-on', both representing less than 0.1% of islet cells). The gene discussed is MYC; the disease is neoplasm.