Islet tumours were induced in nine mice by activation of c-MycERTAM (c-Myc) in β-cells of adult pIns-c-MycERTAM mice cross-bred with RIP7-Bcl-xL mice [22] by daily intraperitoneal (IP) administration of 4-OHT for 14 days as previously described [9]. This evidence concerns the gene MYC and neoplasm.