MYC and sarcoma: In contrast to the osteogenic sarcoma model, reactivation of c-Myc in growth arrested, redifferentiated keratinocytes did not result in increased apoptosis, despite the absence of an anti-apoptotic lesion (Figure 5), but again resulted in increased levels of suprabasal proliferation extending beyond the basal compartment (Figure 5); but as in the c-Myc 'on', no replicating cells were present in the granular layer.