Herein, we demonstrate that among eight human bladder tumour cell lines (5637 (Fogh, 1978), BFTC905 (Tzeng et al, 1996), HT1197 (Rasheed et al, 1977), J82 (O'Toole et al, 1978), SCaBER (Cheng et al, 1995), T24 (Reddy et al, 1982; Tabin et al, 1982), TSGH-8301 (Yeh et al, 1988), and TCCSUP (Nayak et al, 1977) ) tested for the susceptibility of genistein-induced growth inhibition, only the activated H-ras-harbouring T24 cells were consistently resistant to this drug treatment. Here, HRAS is linked to urinary bladder neoplasm.