Using this approach, we have previously reported that several candidates including hepsin, stratum corneum chymotryptic enzyme (SCCE/KLK7), protease M (KLK6), TADG-12, and TADG-14 (KLK8) are abundantly expressed in ovarian cancers (Tanimoto et al, 1997, 1999, 2001a; Underwood et al, 1999, 2000). The gene discussed is KLK8; the disease is ovarian cancer.