BIRC5 and neoplasm: A recent report from the same research group showed that apoptosis inhibition by Tg expression of survivin enhances mutant clone creation and malignant progression during UV-B treatments in the skin carcinogenesis model, but inhibition of apoptosis by survivin in the neighbour survivin-Tg-transgenic skin cells restricts mutant clone expansion (tumour formation) (Zhang et al, 2004c).