Interestingly, it was recently reported that inhibition of Wnt-2 signalling, by either a novel monoclonal antibody against human Wnt-2 ligand or Wnt-2 small interfering RNA, downregulates β-catenin and survivin, and induces apoptosis in Wnt-2-overexpressing human melanoma (You et al, 2004a) and non-small-cell lung cancer cells (You et al, 2004b), but not in normal cells lacking Wnt-2 expression. This evidence concerns the gene WNT2 and melanoma.