Lin et al (2003) showed that the positivity of survivin significantly increased in the transition from normal mucosas (0.0%) to adenomas with low-grade dysplasia (31.7%) to high-grade dysplasia (56.7%) or carcinomas (63.2%) although survivin expression was not associated with the histological differentiation grade of colorectal carcinoma. The gene discussed is BIRC5; the disease is carcinoma.