DNMT3B and neoplasm: On hierarchically clustering the tumor samples according to the expression of the three most discriminatory genes i.e. the genes with the highest ROC-AUC values (BRCA2, DNMT3B and CCNE1, ROC-AUC: 0.696, 0.690 and 0.674, respectively), the patient population fell into two subgroups (65 and 35 subjects, respectively) with significantly different relapse-free survival curves (log-rank test, P = 0.007; Figure 1A) (5-year RFS rate 66.9% ± 8.1 versus 83.9% ± 4.6; 10-year RFS rate 41.0% ± 8.7 versus 67.0% ± 6.6).