The aim of this study was to detect the expression of MUC1 in human primary tumour tissues and three pancreatic cancer cell lines (CAPAN-1, CFPAC-1 and PANC-1), and target MUC1-positive cancer cells in vitro using 213Bi-C595 alpha-immunoconjugate (AIC). The gene discussed is MUC1; the disease is familial pancreatic carcinoma.