The fact that both Id-1 and EGFR protein expression levels increase with progression and poor prognosis as well as chemoresistance of ovarian cancer (Alper et al, 2001; Maihle et al, 2002; Schindl et al, 2003; Cloven et al, 2004) raises a hypothesis that these two proteins may either share similar functions or regulate through same pathways. The gene discussed is ID1; the disease is ovarian carcinoma.