Although the Id-1-induced cell proliferation in normal as well as in cancer cells has been reported in several previous studies (Lin et al, 2000; Ouyang et al, 2002b; Wang et al, 2002b), this study is the first to demonstrate its positive role on ovarian cancer cell growth, especially its relation with EGFR pathway in ovarian cancer cells. The gene discussed is EGFR; the disease is ovarian cancer.