The E2-induced expression profile of E2F1, a key transcriptional regulator of DNA replication genes (Ohtani 1999), closely parallels the induction of the chromosome replication genes (Figure 6B), consistent with the proposal that E2F1 regulates the expression of components of the DNA replication fork in human breast cancer cell lines exposed to E2 (Lobenhofer et al. 2002). The gene discussed is E2F1; the disease is breast carcinoma.