The mutations in AD-EDMD are distributed throughout the coiled-coil domain and the first half of the C-terminal globular domain of lamin A. LGMD and DCM appear to be caused mainly by mutations in the coiled-coil domain [19], although an R571S mutation at the end of the globular domain, that affects only lamin C, has been found in a mild case of DCM. The gene discussed is LMNA; the disease is familial dilated cardiomyopathy.