ACE and neoplasm: However, according to the serotyping, only the HLA-A2.1 subtype was shared between the primary HER-2/neu-overexpressing Ova-1, Ova-2 and Ova-3 tumours (which served as source for the ACE preparation) and the SKOV3 or SKBR3 tumour cell lines and therefore only HER-2/neu peptide-specific and HLA-A2.1-restricted CTL clones would have a chance to recognise them.