HPN and Familial prostate cancer: Previously established markers of prostate cancer such as KLK2, KLK3 (PSA) and FOLH1 (PSMA) were commonly highlighted and an additional cohort of genes consistently upregulated in prostate cancer emerged including Hepsin, AMACR and FASN. Meta-analysis of several of these studies (Rhodes et al, 2002) additionally revealed altered transcription of many genes involved in polyamine and purine biosynthesis pathways in prostate cancer.