These findings are in agreement with previous reports demonstrating that Tpl2/Cot is involved in TNF-α expression and secretion [7,15] while provide evidence for a causal relationship between the Tpl2/Cot overexpression, the TNF-α overproduction and the pathogenesis of neutropenia in LGL-PD patients [25]. This evidence concerns the gene TNF and Decreased total neutrophil count.