It is of interest that the patient with chronic NK-lymphocytosis and neutropenia displayed the highest TNF-α value (6.2 pg/ml) that was associated with the highest Tpl2/Cot expression (5.2 fold compared to control) (Table 3) suggesting a relationship between Tpl2/Cot overexpression and TNF-α overproduction in this patient. Here, MAP3K8 is linked to Decreased total neutrophil count.