In the present study, reactivation and/or increased expression of FHIT, cyclin-D2 and RUNX3 in C13*, FANCF in TOV-21G and cyclin-D2 in OV-90 cell line after exposure to DAC in the absence of promoter methylation suggests that key histone modifications, either by direct or indirect involvement of promoter methylation, also play a role in down-regulating FANCF gene expression in this cancer type. The gene discussed is FHIT; the disease is cancer.