Two large-scale trials, the Scandinavian Simvastatin Survival Study (4S) [20] and the Cholesterol and Recurrent Events (CARE) [21] study, had showed that the use of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, simvastatin and pravastatin, respectively, substantially reduced cardiovascular events hypercholesterolaemic and in general post-MI populations. The gene discussed is HMGCR; the disease is myocardial infarction.