This site is sensitive to environmental carcinogens (Schantz et al, 2000) and is located between intron 3 and intron 7 of a putative tumour suppressor gene, fragile histidine triad (FHIT), which has proapoptotic activity (Ji et al, 1999; Sard et al, 1999; Dumon et al, 2001; Roz et al, 2002). Here, FHIT is linked to neoplasm.