It has also been observed that the tumor-suppressor PTEN, the Akt/PKB pathway inhibitor [17], was down-regulated drastically, leading to an increased activity of Akt/PKB, as shown by the anti-apoptotic protein Bcl-2 and the cell-cycle inhibitor p27kip, which were induced and inhibited, respectively. The gene discussed is BCL2; the disease is neoplasm.