Significant increases in absolute counts of lymphocytes (p = 0.004), CD3+ T-cells (p = 0.0087), CD4+ T-cells (p = 0.012) and CD4+HLA-DR+ (p = 0.05) as well as in the percentage of CD3+ T-cells (p = 0.05) in otitis prone (n = 5) compared to otitis free (n = 6) Turner girls was shown. This evidence concerns the gene CD4 and ear infection.