A significant correlation with MMP-2 gene expression implies that the regulation of MMP-2 may be a possible mechanism underlying the effect of SPARC on the progression of oesophageal and bladder cancer (Ledda et al, 1997; Thomas et al, 2000; Yamanaka et al, 2001; Yamashita et al, 2003). This evidence concerns the gene SPARC and urinary bladder cancer.