As shown in Fig. 7, line-2, AAT added to HCC cells was unchanged in amount and form compared to native AAT alone (Fig. 7, line-5), whereas AAT added as a supplement into PMN-conditioned medium is altered in the distribution of its forms: in addition to monomeric AAT, a complexed form of AAT can be detected (Fig. 7, lane-4). Here, SERPINA1 is linked to hepatocellular carcinoma.