Our data for the first time show that by activation of multiple inter-related signaling pathways (PI3K/Akt and MAPK) and cell type-specific modulation of expression or activity of caspases, saposin C and/or its precursor (prosaposin) serve as a survival and anti-apoptotic factor for both AS- and AI-prostate cancer cells. Here, PSAP is linked to prostate cancer.