To examine the involvement of GPCR in saposin C-activation of the Akt-signaling pathway as well as the possibility of MAPK and Akt cross-signaling initiated by saposin C, we evaluated the effect of saposin C on p42/44 MAP kinase activation in prostate cancer cells in the presence or absence of various inhibitors. Here, AKT1 is linked to Familial prostate cancer.