The chemotactic response of melanoma cells to IL-8 was mediated by CXCR1 (Ramjeesingh et al, 2003), and the mitogenic activity of IL-8 was mediated by both CXCR1 and CXCR2 in colon cancer (Li et al, 2001), but only by CXCR1 in monocytes (Browning et al, 2000). This evidence concerns the gene CXCR1 and malignant colon neoplasm.