Protection against falciparum malaria has been found to be associated with the preferential production of the cytophilic classes, IgG1 and IgG3, of antibodies [12], this being related to their ability to cooperate with blood monocytes in an ADCC-like (Antibody-Dependant Cellular cytotoxicity) mechanism [13]. The gene discussed is IGHG3; the disease is Plasmodium falciparum malaria.