Besides, common thrombotic risk factors which include also a bad lifestyle (e.g. obesity, non regard to Mediterranean diet, sedentary life), a lot of molecular thrombotic risk factors such as inherited or acquired clotting inhibitor deficiency (i.e. protein C, protein S, antithrombin III), inherited thrombophilia (factor V Leiden, prothrombin A20210G mutation), primary or secondary hyperhomcysteinemia, primary or secondary antiphospholipid syndrome and increased plasma factor VIII levels have been identified [21]. This evidence concerns the gene PROS1 and inherited thrombophilia.