CD40LG and protein S deficiency: Seven patients of group B (50%) showed inherited and/or acquired thrombophilia (one MTHFRC677T homozygosity, one FVL heterozygosity, five PTHRA20210G heterozygosity, none inherited Protein S deficiency, protein C deficiency, AT III deficiency, none presence of lupus anticoagulant, none with increased anticardiolipin autoantibodies IgM and/or IgG), as reported in table 2 ('see additional file 2').