Progression to EMT through a myoepithelial stage was observed in Myc-, Hras-, and SV40-TAg-induced carcinomas, a subset of spontaneous mammary carcinomas in PL/J and SJL/J mice, and has also been reported in mice transgenic for Tgfa [39] and matrix metalloproteinase 3 [40]. The gene discussed is HRAS; the disease is breast carcinoma.