HLA DR3-DQ2-C4AQ0 in combination with FcγRIIa R/R, FcγRIIIa F/F, or MBL-low was still associated with SLE but did not significantly increase the odds ratio (OR) in comparison with HLA DR3-DQ2-C4AQ0 alone. Here, MBL2 is linked to systemic lupus erythematosus.