F2 and Cirrhosis: Markers of severe alcoholic hepatitis or cirrhosis include elevated levels of bilirubin (a yellow-orange substance generated in the liver), prolonged time required for a blood sample to clot (i.e., prothrombin time [PT]), and a low level of the main circulating protein in the bloodstream (i.e., albumin), which is synthesized by the liver (i.e., hypoalbuminemia).