TGFA and hepatocellular carcinoma: Although human HCC often do not express GSTp due to epigenetic silencing of the gene, GSTp+ lesions of rats and (pre)malignant lesions in human liver show significant similarities, such as mutations of the wnt-pathway, overexpression of TGFα, IGF-I and -II and other growth factors (Miller et al, 1995; Grisham, 1997; Yamada et al, 1999; Yang et al, 2003).