The following variables were significantly associated with VIS at univariate analysis: CDC stage A (p < 0.01), high adherence to HAART (p = 0.02), dyslipidemia as adverse effect of HAART (p < 0.01), CD4+ T cell number at baseline and at 6,12,18,24,30,36 months of HAART (p < 0.01), enhancement of CD4+ T cellcount in the first six months (p < 0.01), HIV viral load at 6 (p = 0.04) and 30 months (p = 0.01). The gene discussed is CD4; the disease is metabolic syndrome.