Cox's (proportional-hazards) regression identified preoperative PSA (P<0.0001), pathological Gleason grade (P=0.0178), pathological stage (<0.0001) and margin status (<0.0001) as significant predictors of PSA recurrence for the 671 patients without lymph node metastases and after other exclusions. Here, KLK3 is linked to metastatic malignant neoplasm in the lymph nodes.