FGF2 and Miyoshi myopathy: Cheng et al (1999) found that a high pretreatment microvessel density (MVD) predicted a poor response to THAL therapy, but this needs confirmation in a larger study. Neben et al (2001) reported that high plasma bFGF concentration is associated with a better response to THAL in progressive MM. Dmoszynska et al (2001), (2002) found that the major response to THAL was observed in patients with the highest VEGF pretreatment level compared to patients with a minor response.