SLC2A9 and ischemia: Urate reabsorption increased in setting of increased renal vascular resistance, microvascular disease predisposes to tissue ischemia that leads to increased urate generation (excess purine metabolism) and reduced excretion (due to lactate competing with urate transporter in the proximal tubule).Increased oxidative – redox stressAntioxidant – Prooxidant Paradox:Urate Redox Shuttle