However, Harada et al (2002b) detected no or little promoter methylation of p16INK4A (0%), MGMT (0%), RARB (0%), DAPK (0%), APC (0%), CDH13 (0%), CDH1 (6%) and GSTP1 (3%) in primary neuroblastoma tumours. This evidence concerns the gene RARB and neuroblastoma.