Thus, CASP8 promoter methylation has been reported in ∼50% of neuroblastomas by us and other (Teitz et al, 2000; Astuti et al, 2001c; Harada et al, 2002a) and RASSF1A promoter methylation also occurs frequently (52–55% (Astuti et al, 2001c; Harada et al, 2002b). Here, RASSF1 is linked to neuroblastoma.