RASSF1 and neuroblastoma: In addition, we note that the critical neuroblastoma suppressor gene interval defined by Ejeskar et al (2001) (D1S508 to D1S244) and the 500 kb 1p36.2 – p36.3 homozygous deletion in a neuroblastoma cell line reported by Ohira et al (2000), both map >4 Mb telomeric to SDHB. CASP8 and RASSF1A methylation in neuroblastoma is associated with transcriptional downregulation, but in contrast SDHB promoter methylation did not impair SDH enzyme activity.