In addition, we note that the critical neuroblastoma suppressor gene interval defined by Ejeskar et al (2001) (D1S508 to D1S244) and the 500 kb 1p36.2 – p36.3 homozygous deletion in a neuroblastoma cell line reported by Ohira et al (2000), both map >4 Mb telomeric to SDHB. CASP8 and RASSF1A methylation in neuroblastoma is associated with transcriptional downregulation, but in contrast SDHB promoter methylation did not impair SDH enzyme activity. This evidence concerns the gene CASP8 and neuroblastoma.