AKT1 and breast cancer: Our further evaluations in human prostate and breast cancer cell lines showed that API-59CJ-OMe potently inhibits cell growth and induces apoptosis in cell lines with high levels of p-AKT, but has minimal activity in cell lines with low levels of p-AKT (Wang and Yang, manuscript in preparation), suggesting that API-59CJ-OMe may target the AKT pathway.