HNRNPK and embryonal carcinoma: The targets of some miRNAs were strongly enriched in certain categories, e.g., miR-105 in “small GTPase mediated signal transduction” (5-fold), miR-208 in “transcription factor” (6-fold), and miR-7, which lies in the intron of the hnRNPk (an RNA-binding protein) gene, in “RNA binding proteins.” Neuronal differentiation of embryonic carcinoma cells by retinoic acid in both mice and humans is coupled to induction of let-7b, miR-30, miR-98, miR-103, and miR-135 (Sempere et al. 2004), and their targets are enriched in “neurogenesis” (3.5-fold).