FAS and malignant colon neoplasm: Some authors hypothesised that colon cancer cells are resistant to FasR-mediated apoptosis due to the presence of inhibitory proteins in the Fas signal transduction pathway (Ding et al, 1998; Krammer et al, 1998; O'Connell et al, 1998; Yoong et al, 1999; Vermijlen et al, 2001).