Loss of heterozygosity on human chromosome 17p, 53 point mutations, and altered p53 expression were reported in astrocytomas (Scheffner et al, 1990; Werness et al, 1990; Fujimaki et al, 1991; Lowe and Ruley, 1993; Chozick et al, 1994a; Iuzzolino et al, 1994; Slebos et al, 1994; Morita et al, 1996; Sarkar et al, 2002). The gene discussed is TP53; the disease is astrocytoma (excluding glioblastoma).