Increased p53 expression occurred in the recurrent vs the initial tumour pairs from the same patient, while tumours recurring within the same histologic grade category, failed to reveal this increase (Chozick et al, 1994a; Iuzzolino et al, 1994; Korkolopoulou et al, 1998; Sarkar et al, 2002). This evidence concerns the gene TP53 and neoplasm.