For the first time to our knowledge we show that the TK inhibitor, Tyrphostin AG1024, increases the levels of DNA-PKcs levels with a concomitant decrease in the expression of Bcr-Abl, suggesting that the use of AG1024 could be beneficial for the restoration of DNA-PKcs mediated repair in CML cells. This evidence concerns the gene TKT and chronic myelogenous leukemia, BCR-ABL1 positive.