This work was partially supported by AIRC 2002, Investigator Grant title: ‘Clusterin and polyamine regulatory genes as new molecular markers for prostate cancer prognosis and therapy’; Ministero dell'Istruzione, dell'Università e della Ricerca (Fondo Integrativo Speciale per la Ricerca 2001); and program support from Yorkshire Cancer Research. This evidence concerns the gene CLU and Familial prostate cancer.