It has already been reported[2-5,10,11] that the toxicity of TNF in phase I or II clinical trials are mainly chill, fever, local redness, swelling and pain, hypotension, nausea, vomiting, myalgia, fatigue and diarrhea, while pulmonary hemorrhage and severe hepatic dysfunction also have been observed[12]. This evidence concerns the gene TNF and Pulmonary hemorrhage.