TNF and neoplasm: Studies have shown that the anti-tumor mechanism of the tumor necrosis factor includes 1) killing the tumor cell directly [3]; 2 inducing the apoptosis of tumor cells [3]; 3) reversing more drug resistance of tumor cell and improving the sensitiveness of chemotherapy [3]; 4) destroying the blood supply of tumor tissue [4]; 5) increasing the killing effects of immune-effect cells on the tumor cells [3].