These factors include inherited conditions (e.g. Factor V Leiden, RR = 50, Antithrombin deficiency, RR = 25, Protein C and S deficiency, RR = 10); acquired conditions (e.g. major surgery or trauma, RR = 5–200; history of venous thromboembolism, RR = 50); and hereditary, environmental, or idiopathic conditions (e.g. hyperhomocysteinemia, and elevated levels of Factor VIII, RR = 3: elevated levels of Factor IX, RR = 2.3). The gene discussed is F5; the disease is hereditary antithrombin deficiency.