These include the p160 family of coactivator proteins, steroid receptor coactivator 1 (SRC-1) and amplified in breast cancer 1 (AIB1), both of which have intrinsic histone acelyl-transferase activity which enhance transcription by enabling access of transcription factors and RNA polymerase II core machinery to target DNA (Spencer et al, 1997; Liao et al, 2002). The gene discussed is NCOA1; the disease is cancer.