Some of those have previously been documented in studies that did not involve expression profiling as cancer related genes (Human monocyte-derived neutrophil-activating protein (MONAP) and Human hepatoma mRNA for serine protease hepsin), others (Human gene for heterogeneous nuclear ribonucleoprotein (hnRNP), P24480 CALGIZZARIN, Human mitochondrial matrix protein P1, Human mRNA for aldose reductase and human adipsin) have not been identified from in-silico studies of tissue DNA-array expression data. The gene discussed is AKR1B1; the disease is hepatocellular carcinoma.