Taken together, these observations suggest that squamous cell carcinomas that are generally positive for S100A2 expression and S100A2 positive adenocarcinomas may arise either from the multipotent basal cells of the bronchial epithelium or else from a stem cell progenitor which expresses this and other tumour-associated genes (maspin, ΔNp63). This evidence concerns the gene S100A2 and neoplasm.