The most compelling evidence that MYC is causally associated with the etiology of HCC comes from animal models (Sandgren et al. 1989; Fourel et al. 1990; Murakami et al. 1993; Morgenbesser and DePinho 1994; Sargent et al. 1996, 1999; De Miglio et al. 1999; Santoni-Rugiu et al. 1999; Renard et al. 2000). Here, MYC is linked to hepatocellular carcinoma.