TP53 and cancer: Antibodies against nontissue specific intracellular or cell-surface proteins are seen in several types of cancer, such as antibodies against p53 (Crawford et al, 1982), oncogene products such as ras (Cheever et al, 1995), cellular proteins such as p62 (Zhang et al, 1999) and cell cycle proteins such as cyclin B1 (Covini et al, 1997).