IGHG3 and Hepatosplenomegaly: Recently, it was observed that IgG3 antibody responses to P. falciparum schizont antigen (Pfs Ag) were higher in Kenyan children with S. mansoni infection and hepatosplenomegaly compared with children with infection but no hepatosplenomegaly [11], further implicating exposure to malaria in childhood as a risk factor for severe hepatosplenic morbidity.