Factors that affect prognosis are age, sex, race, white blood cell count at diagnosis, phenotypic differences, such as T-cell versus B-cell lineage ALL and karyotypic alterations, such as the hyperdiploid karyotype and the translocations t(12;21)[TEL-AML1], t(4;11)[MLL-AF4], t(9;22)[BCR-ABL], and t(1;19)[E2A-PBX] [7,9]. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.