In face of the increasing incidence of CRC and its peculiar pattern in the Egyptian population, the present study was conducted to assess the role of Ki-67 (pan-cell cycle marker), cyclin D1 (G1 phase marker), histone H3 mRNA (S phase marker), cyclin A (S to G2 phase marker) in CRC. This evidence concerns the gene CCNA2 and colorectal carcinoma.