CCND1 and metastatic malignant neoplasm in the lymph nodes: Cox regression analysis revealed that cyclin A overexpression (our definition: SI ≥ 10.5), cyclin D1 overexpression (our definition: SI ≥ 6.1), poorly differentiated histology, lymph node metastasis, TNM stage, tumor size and depth of invasion were all significant prognostic variables for survival (Table 3).