In a study by Gao et al., examining p53 mutations through exons 5–8 in patients with squamous cell carcinoma and adenocarcinoma of the lung [15], it was shown that patients with adenocarcinoma expressed mutational hotspots at codons 248 and 249, whereas patients with squamous cell carcinoma had mutational events spread throughout exons 5–8. This evidence concerns the gene TP53 and lung adenocarcinoma.